This indispensable guide offers detailed coverage of the regulations, requirements, and techniques for the validation of processes and systems used in regulated international industries - addressing all significant requirements for pharmaceutical, medical device, and biologic companies as well as environmental laboratories. Elucidating up-to-the-minute industry changes and international concerns, Validation Compliance Annual 1995 examines Good Manufacturing Practices (GMPs), Good Clinical Practices (GCPs), Good Laboratory Practices (GLPs), and Good Automated laboratory Practices (GALPs)... provides unabridged texts of U.S. and European Union regulatory requirements as well as summaries of the validation requirements of other nations... furnishes complete guidelines and tools for system validation... supplies an in-depth look at problems related to inadequate system validation, including actual regulatory citations for noncompliance... explains the rationale behind regulatory compliance policies and inspectional practices... assesses the future of regulatory and industry trends... and more. Containing key bibliographic citations and a thorough glossary of validation terms, Validation Compliance Annual 1995 is an incomparable day-to-day workbook for analytical, pharmaceutical, food, and environmental chemists; instrumentation specialists; industrial, bio-process, chemical, and pharmaceutical engineers; quality and reliability managers and directors; laboratory managers and technicians; computer scientists; and upper-level undergraduate and graduate students in these disciplines.

During the last ten years a considerable volume of inform ation has been accumulated regarding the inelastic behaviour of materials. The increasing number of communications published in specialised journals and also the frequency of meetings in these fields, indicates a considerable research effort aimed at such topics as plasticity, creep, fatigue, visco-plasticity and the like. This fact encouraged a group of Brazilian researchers, stimulated enthusiastically by Professor P. Germain, to submit a proposal for a Symposium on the "Inelastic Behaviour of Plates and Shells" to the General Assembly of IUTAM. Brazil had recently joined IUTAM and the Brazilian Association of Mechanical Sciences was eager to host an IUTAM meeting. In the selection of the subject, it was taken into account, besides a promising number of original contributions, the interest to be raised amongst the Brazilian researchers and engineers, in order to maximise the participation of the host country. The recent steps taken in this country towards the develop ment of the aero-space industry, the construction of nuclear power plants a.nd the off-shore exploration of petroleum have required an intensification of research activities in several fields, structural behaviour of plates and shells being one of the most important. Therefore, the suggested theme would attract the interest or a significant group of Brazilian researchers and engineers and match the necessity for exchanging experience among leading scientists working in those fields."

The United States Social Security Administration (SSA) administers two disability programs: Social Security Disability Insurance (SSDI), for disabled individuals, and their dependent family members, who have worked and contributed to the Social Security trust funds, and Supplemental Security Income (SSSI), which is a means-tested program based on income and financial assets for adults aged 65 years or older and disabled adults and children. Both programs require that claimants have a disability and meet specific medical criteria in order to qualify for benefits. SSA establishes the presence of a medically-determined impairment in individuals with mental disorders other than intellectual disability through the use of standard diagnostic criteria, which include symptoms and signs. These impairments are established largely on reports of signs and symptoms of impairment and functional limitation. Psychological Testing in the Service of Disability Determination considers the use of psychological tests in evaluating disability claims submitted to the SSA. This report critically reviews selected psychological tests, including symptom validity tests, that could contribute to SSA disability determinations. The report discusses the possible uses of such tests and their contribution to disability determinations. Psychological Testing in the Service of Disability Determination discusses testing norms, qualifications for administration of tests, administration of tests, and reporting results. The recommendations of this report will help SSA improve the consistency and accuracy of disability determination in certain cases. Table of Contents Front Matter Summary 1 Introduction 2 Disability Evaluation and the Use of Psychological Tests 3 Overview of Psychological Testing 4 Self-Report Measures and Symptom Validity Tests 5 Cognitive Tests and Performance Validity Tests 6 Economic Considerations 7 Conclusions and Recommendations Appendix A: Public Workshop Agendas Appendix B: Biographical Sketches of Committee Members Appendix C: Glossary

Advances in computing hardware and algorithms have dramatically improved the ability to simulate complex processes computationally. Today's simulation capabilities offer the prospect of addressing questions that in the past could be addressed only by resource-intensive experimentation, if at all. Assessing the Reliability of Complex Models recognizes the ubiquity of uncertainty in computational estimates of reality and the necessity for its quantification. As computational science and engineering have matured, the process of quantifying or bounding uncertainties in a computational estimate of a physical quality of interest has evolved into a small set of interdependent tasks: verification, validation, and uncertainty of quantification (VVUQ). In recognition of the increasing importance of computational simulation and the increasing need to assess uncertainties in computational results, the National Research Council was asked to study the mathematical foundations of VVUQ and to recommend steps that will ultimately lead to improved processes. Assessing the Reliability of Complex Models discusses changes in education of professionals and dissemination of information that should enhance the ability of future VVUQ practitioners to improve and properly apply VVUQ methodologies to difficult problems, enhance the ability of VVUQ customers to understand VVUQ results and use them to make informed decisions, and enhance the ability of all VVUQ stakeholders to communicate with each other. This report is an essential resource for all decision and policy makers in the field, students, stakeholders, UQ experts, and VVUQ educators and practitioners. Table of Contents Front Matter Summary 1 Introduction 2 Sources of Uncertainty and Error 3 Verification 4 Emulation, Reduced-Order Modeling, and Forward Propagation 5 Model Validation and Prediction 6 Making Decisions 7 Next Steps in Practice, Research, and Education for Verification, Validation, and Uncertainty Quantification Appendixes Appendix A: Glossary Appendix B: Agendas of Committee Meetings Appendix C: Committee Biographies Appendix D: Acronyms

Eyewitnesses play an important role in criminal cases when they can identify culprits. Estimates suggest that tens of thousands of eyewitnesses make identifications in criminal investigations each year. Research on factors that affect the accuracy of eyewitness identification procedures has given us an increasingly clear picture of how identifications are made, and more importantly, an improved understanding of the principled limits on vision and memory that can lead to failure of identification. Factors such as viewing conditions, duress, elevated emotions, and biases influence the visual perception experience. Perceptual experiences are stored by a system of memory that is highly malleable and continuously evolving, neither retaining nor divulging content in an informational vacuum. As such, the fidelity of our memories to actual events may be compromised by many factors at all stages of processing, from encoding to storage and retrieval. Unknown to the individual, memories are forgotten, reconstructed, updated, and distorted. Complicating the process further, policies governing law enforcement procedures for conducting and recording identifications are not standard, and policies and practices to address the issue of misidentification vary widely. These limitations can produce mistaken identifications with significant consequences. What can we do to make certain that eyewitness identification convicts the guilty and exonerates the innocent? Identifying the Culprit makes the case that better data collection and research on eyewitness identification, new law enforcement training protocols, standardized procedures for administering line-ups, and improvements in the handling of eyewitness identification in court can increase the chances that accurate identifications are made. This report explains the science that has emerged during the past 30 years on eyewitness identifications and identifies best practices in eyewitness procedures for the law enforcement community and in the presentation of eyewitness evidence in the courtroom. In order to continue the advancement of eyewitness identification research, the report recommends a focused research agenda. Identifying the Culprit will be an essential resource to assist the law enforcement and legal communities as they seek to understand the value and the limitations of eyewitness identification and make improvements to procedures.